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Presentations

Alcohol use disorders and sleep disruption


Early recognition and treatment of alcohol use disorders

  • Ambivalence and internal discrepancy

    Part 1 of lecture series Motivating patients with alcohol problems

    Patients often face two opposite strong feelings that are conflicting one against the other – to drink and to stay sober.

    Presentation: Antoni Gual

    Duration: 0:06:24

  • Values of life to explore

    Part 2 of lecture series Motivating patients with alcohol problems

    Asking patients about their values will get us closer to what is really important for them, and can help them to find good reasons to make the effort to change their drinking behaviour.

    Presentation: Antoni Gual

    Duration: 0:14:43

  • Guiding the process of change

    Part 3 of lecture series Motivating patients with alcohol problems

    Just raising internal discrepancies in a motivational interview is not enough to bring about a change.

    Presentation: Antoni Gual

    Duration: 0:16:40

  • What is a good treatment outcome?

    Breakout session highlight, Anne Lingford-Hughes

    The key is to be individually tailored − success for one individual may not look like success for another.
  • Key messages about the management of relapse

    Breakout session highlight, Anne Lingford-Hughes

    If people are doing badly in diabetes, asthma or hypertension, we don’t tend to discharge them, whereas that is often exactly what happens to a person with an alcohol problem.
  • Key messages about motivational interviewing

    Breakout session highlight, Antoni Gual

    Motivation is also something we need to work on with the team. It doesn’t help that much if you are trying to be very motivating with the patient while the rest of your team is confronting them.

Alcohol use disorders and depression

  • Diagnostic challenges

    Part 1 of lecture series Alcohol dependence and depression: cause or consequence?

    Many major depressive symptoms can be related to an underlying alcohol use disorder – to acute intoxication, chronic high risk drinking and alcohol withdrawal.
  • Risk factors and causal relationships

    Part 2 of lecture series Alcohol dependence and depression: cause or consequence?

    Major depression can induce alcohol use disorder, and conversely alcohol use disorder can induce major depression. But in a given patient, what came first?
  • A relationship that goes two ways

    Part 3 of lecture series Alcohol dependence and depression: cause or consequence?

    A significant number of depressed alcohol dependent patients will undergo a rapid improvement of depressive symptoms and subsequent normalisation of mood following medically assisted withdrawal, the effect of this can be striking to both patient and clinician.
  • Supportive text messaging for depression and comorbid alcohol use disorders

    Highlight from presentation Future horizons in patient care using social media and new technology

    Computer-driven text messages like “If you are having a good day, share it with others; if you are having a bad day share, it with others and accept their help” can help support depressive symptoms
  • Alcohol dependence and depression: cause or consequence?

    Breakout session highlight

    For patients with an alcohol use disorder and a comorbid depressive disorder, we should treat alcohol misuse first. This may lead to a significant improvement in depression.
  • Alcohol Dependence - from Disease to Treatment

    Presentation at EPA 2014 by Prof. Dr. Henri-Jean Aubin, University Paris Sud, France

    Alcohol dependence is highly prevalent and wide-spread among people of all ages and socioeconomic groups, and has enormous health consequences...

Alcohol and hypertension

  • Mechanistic insights into a dilemma

    Part 1 of lecture series Alcohol as a risk factor for hypertension

    In the same way that alcohol causes structural changes within the liver it also produces changes within the heart.

    Presentation: Daniel Duprez

    Duration: 00:06:52

  • Gender differences in alcohol-induced hypertension

    Part 2 of lecture series Alcohol as a risk factor for hypertension

    There is a proven linear dose−response relationship between alcohol and hypertension. Women who abuse alcohol are at even higher risk to develop more resistant hypertension.

    Presentation: Daniel Duprez

    Duration: 00:08:11

  • The silent killer

    Part 3 of lecture series Alcohol as a risk factor for hypertension

    Arterial hypertension can put the patient on an accelerated trajectory for cardiovascular disease. Decreasing alcohol consumption will lead to a parallel decrease in arterial hypertension.

    Presentation: Daniel Duprez

    Duration: 00:10:41

  • The ‘holiday heart’ is not a heart holiday

    Breakout session highlight

    Acute binges of excessive drinking such as on holiday means increased risk due to the extra burden for the heart

    Presentation: Ian Gilmore, Daniel Duprez and Timothy Roehrs

    Duration: 00:02:20

  • Alcohol - an under-recognised risk factor for hypertension

    Breakout session highlight

    Both the link between alcohol and the incidence of hypertension as well as the association regarding the reversibility of hypertension if the patient stops drinking are under-recognised.

    Presentation: Daniel Duprez

    Duration: 00:04:00


Primary care and alcohol use disorders

  • A typical morning in general practice

    Part 1 of presentation How alcohol use disorders affect your practice

    For a wide variety of problems that patients present with in general practice alcohol might have a part to play. It is important to be aware of this and to address alcohol use with our patients. Various validated screening tools for assessing alcohol problems in primary care are available.

  • The role of primary care in alcohol use disorders

    Part 2 of presentation How alcohol use disorders affect your practice

    Identification and brief advice are effective interventions in primary care. Other important roles of primary care in alcohol use disorders are the management of comorbidities and provision of pharmacotherapy. Planning the care in conjunction with the patient is key.

  • Guidelines and terminology

    Part 1 of presentation Tailoring treatment options for patients with alcohol dependence

    Expert guidelines are available on alcohol dependence and how to treat alcohol use disorder.

  • Distinguishing harmful and dependent alcohol consumption

    Part 2 of presentation Tailoring treatment options for patients with alcohol dependence

    In order to make the right choice in treatment options we need to assess severity of alcohol dependence. There are many assessment tools for this.

  • Treatment planning considerations for alcohol use disorders

    Part 3 from presentation Tailoring treatment options for patients with alcohol dependence

    With mild and harmful drinking it may be easier to get people moving in the right direction, but the more severe the dependence the harder it is to treat.

  • Google, Twitter, and Facebook: where are your patients getting information?

    Highlight from presentation Future horizons in patient care using social media and new technology

     The proportion of patients coming to our practice with information from apps, social media, or the Internet has risen dramatically in the last years.

  • Gender considerations in tailoring treatment

    Breakout session highlight - Ian Gilmore and Anne Lingford-Hughes

    In tailoring treatment, we may need to think about women slightly differently.

  • Keys to communication

    Breakout session highlight - Ian Gilmore and Antoni Gual

    We can’t change a patient’s ambivalence by just telling him what he has to do.


New treatments in alcohol use disorders

  • Neurobiology and pharmacological treatments

    Part 1 of presentation The pharmacological toolbox for the treatment of patients with alcohol dependence

    We know where the functions are disturbed, and we know which brain structures are involved more or less – we know most of this from animal research but also lately of course from the neuroimaging studies. We also have some ideas about which neurotransmitters are involved, and we know that we can start to develop medications.

  • A spectrum of available treatments

    Part 2 of presentation The pharmacological toolbox for the treatment of patients with alcohol dependence

    A range of new pharmacological treatments is available with different modes of action and for different goals - for abstinence and reduced drinking. People sometimes start with reduced drinking and then move to abstinence, or they start with abstinence as their treatment goal and then move to reduced drinking. We should be flexible about this, because it is not written in stone.

  • Focus on nalmefene - part one

    Part 3 of presentation The pharmacological toolbox for the treatment of patients with alcohol dependence

    A brief explanation of the pharmacokinetics of nalmefene, and presentation of results from three large randomised controlled trials conducted in patients with alcohol dependence, comparing nalmefene with placebo.

  • Focus on nalmefene - part two

    Part 4 of presentation The pharmacological toolbox for the treatment of patients with alcohol dependence

    Standardised effect sizes for nalmefene compare to those of other medications like antipsychotics and antidepressants. Nalmefene has a good safety profile; the most frequent treatment-emergent adverse events are transient and patients need to be informed of these to increase compliance.

  • Web-based self-help for problem drinkers: minderdrinken.nl

    Highlight 1 of presentation Future horizons in patient care using social media and new technology

    A web-based, multi-component, interactive self-help intervention can help problem drinkers reduce their alcohol consumption.

  • Computerized cognitive behavioural therapy for alcohol use disorders

    Highlight 2 of presentation Future horizons in patient care using social media and new technology

    In a trial of people with alcohol dependence, self-help group attendance increased in a computerized cognitive behavioural therapy group, and this therapy was associated with higher self-efficacy and higher outcome expectancy versus a control group.

  • New approaches for outpatient interventions

    Highlight 3 of presentation Future horizons in patient care using social media and new technology

    A computer-based multi-media platform using graphics, video tapes, verbal instructions and interactive assessments can be a valuable adjunct to standard therapy.  

  • Online learning resources for healthcare professionals

    Highlight 4 of presentation Future horizons in patient care using social media and new technology

    Online tools can be very effective in terms of learning for medical professionals.

  • The need for expanding the treatment continuum in the treatment of alcohol dependence

    Presentation at ECNP 2012 from Prof. Dr. Wim van den Brink, Dept. of Psychiatry, Academic Medical Center Amsterdam, The Netherlands

    Alcohol remains as one of the largest risk factors for global burden of disease and injury. Despite the heavy burden of alcohol, patients with alcohol dependence are currently under-diagnosed and under-treated.


The “must-be-known” neurobiology of alcohol use disorders

  • How to find genes that underlie alcohol dependence?

    Highlight 1 of presentation Genetics of alcohol dependence, and treatment implications

    Genes count – they are involved in the risk of having a dependence in your life.
  • The Dopamine « star » genes

    Highlight 2 of presentation Genetics of alcohol dependence, and treatment implications

    Two hypotheses to explain how dopamine genes are involved in alcohol dependence.
  • Endophenotype

    Highlight 3 of presentation Genetics of alcohol dependence, and treatment implications

    Testing the inhibition process with the stop-signal reaction-time reveals an endophenotype shared by affected patients and non-affected relatives.
  • The pharmacogenetics of naltrexone, ondansetron, and nalmefene

    Highlight 4 of presentation Genetics of alcohol dependence, and treatment implications

    Pharmacogenetic aspects can be relevant for everyday practice, when specific polymorphisms are significantly associated with higher chances of treatment success.
  • Imaging brain structure

    Part 1 of presentation Visualizing the alcohol-dependent brain

    Extremely powerful imaging techniques now enable us to show and measure structural changes in the brain caused by alcohol.
  • Functional imaging

    Part 2 of presentation Visualizing the alcohol-dependent brain

    Using functional imaging technology we can visualize how certain brain circuits are activated and measure brain networks like the default...
  • Dopamine, GABA-alpha and other receptors

    Part 3 of presentation Visualizing the alcohol-dependent brain

    Activity and dysregulation of receptors involved in addiction, sedation, ataxia, inhibition and loss of control can now be visualized using...
  • PET and MEG imaging

    Part 4 of presentation Visualizing the alcohol-dependent brain

    Opioid receptors involved in craving can be measured with PET, and with this technique we can now show how alcohol...
  • Neurobiology of alcohol dependence

    Presentation at ECNP 2013 from Prof. Dr. Anne Lingford-Hughes, Professor of Addiction Biology at Imperial College London, United Kingdom.

    Alcohol dependence is a brain disease with a progressive, and relapsing, course. Increased understanding of the neurobiology of alcohol dependence...

Alcohol use Disorders: Burden of Disease


EPA 2014

  • Alcohol Dependence - from Disease to Treatment

    Presentation at EPA 2014 by Prof. Dr. Henri-Jean Aubin, University Paris Sud, France

    Alcohol dependence is highly prevalent and wide-spread among people of all ages and socioeconomic groups, and has enormous health consequences...
  • Clinical relevance of alcohol reduction

    Presentation: Prof. Dr. Jonathan Chick, Castle Craig Hospital, West Linton, Peeblesshire, Scotland

    Traditional methods for treating alcohol dependence have always been focused on total abstinence using psychotherapeutic and pharmacological interventions. However, many...
  • Integration of psychosocial support and pharmacotherapy

    Presentation: Prof. Dr. William D. Dundon, Center for the Studies of Addiction, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, USA

    Patients with alcohol dependence are often only referred to psychosocial support. However, the use of pharmacotherapy may complement psychosocial treatments,...

ECNP 2013

  • Benefits of patient-centred care in alcohol dependence

    Presentation: Prof. Dr. Gerard Schippers, dept. of Psychiatry of the Academic Medical Center Amsterdam, The Netherlands.

    Patient-centred treatment promotes adherence, leads to improved outcomes and to decreased unnecessary utilization of health care services. This research supports...

ECNP 2012

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