Site no longer supporterd

This site is no longer supported and will not be updated with new content. You are welcome to browse and download all content already included in the site. Please note you will have to register your email address to access the site. We expect to close the site down by December 2016.

You are here

Association between alcohol and cardiovascular disease

Michael V. Holmes, Caroline E. Dale, Luisa Zuccolo, Richard J. Silverwood, Yiran Guo, Zheng Ye et al., on behalf of The InterAct Consortium

BMJ 2014;349:g4164

Editor's comment:
The results of this large (more than 260,000 participants) international study challenge the concept of a cardioprotective effect associated with light to moderate alcohol consumption reported in observational studies. In the absence of a viable randomised trial to confirm or refute the cardioprotective effect of light to moderate alcohol consumption, the authors followed an alternative approach in their study, using the ADH1B rs1229984 variant as an instrument to investigate the association of alcohol with cardiovascular biomarkers and events. In the study, individuals with a genetic predisposition to consume less alcohol were found to have a reduced risk of coronary heart disease and ischaemic stroke, and lower levels of several established and emerging risk factors for cardiovascular disease. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.

Related content

Readiness to change and brain damage in patients with chronic alcoholism

Editor's comment:
The main objective of this study was to gain a better understanding of the potential contribution of...

Recent binge drinking predicts smaller cerebellar volumes in adolescents

Editor's comment:
In this study, the authors found that increased binge drinks during the past 3 months significantly predicted smaller...

Effect of the TaqIA polymorphism on ethanol response in the brain

Editor's comment:
Positron emission tomography with [F-18] fluorodeoxyglucose (FDG) was used in this study to assess regional cerebral glucose...

Abnormal white matter integrity and decision-making deficits in alcohol dependence

Editor's comment:
The authors of this study used Tract Based Spatial Statistics (TBSS) to assess white matter changes in...

AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study

Editor's comment:
The authors examined densities of AMPA receptors from human post-mortem brain regions in Cloninger type 1 and...

Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism

Editor's comment:
In this study, resting state functional magnetic resonance imaging was used to examine the intrinsic connectivity of...

Featured presentations

Share

Notify your friends and contacts about this Progress in Mind Resource Centre, with free access to excellent content.

 

 

 

Suggestions

Please tell us what you like us to cover on the Resource Centre – we welcome your suggestions and comments

Search this site

Search form